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ATM appears to play a role in protecting human hair follicle melanocytes from oxidative stress/damage, and maintenance of its expression within the follicle microenvironment along with other redox markers may be important for hair bulb melanocyte survival in canities-prone scalp hair follicles

Lets unpack that more specifically, Glutathione is a part of the glutathione system

The authors also assessed how caffeine interferes with hepatic lipid metabolism by observing a decrease in hepatic mRNA expression of fatty acid synthase and acetyl-CoA carboxylase along with an increase in hepatic carnitine palmitoyltransferase 1 (CPT1) and proliferation-activated receptor , which suggested that the administration of caffeine regulates hepatic de novo lipogenesis and -oxidation [73]

In addition, those who take certain medications may be at increased risk for B12 deficiency, per Healthline